Use Challenge Trials Effectively in Clinical Studies: Lessons Learned from H3N2 Influenza Virus

Challenge trials can be used to shorten clinical development plans successfully when certain criteria are met. For example, the quality of data obtained from challenge trials is in direct relation to the quality of the challenge agent.

With profound antigenic changes occurring in circulating virus strains, there is a pressing need for improved strains of challenge virus representative of prevalent, global subtypes.

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